adderall pills

Antidepressants Addiction: Side Effects, Detox, Withdrawal, and Treatment


Could you have an addiction to antidepressants?
Take this confidential antidepressants use disorder assessment.

What are Antidepressants?

Antidepressants are medications that help relieve symptoms of depression and other disorders, such as anxiety, social anxiety, obsessive-compulsive disorder (OCD), and seasonal affective disorder, among others.1  Although antidepressants were first developed in the 1950s, their use has greatly increased in recent years. They are some of the most commonly prescribed drugs in America. According to data from the National Health and Nutrition Examination Survey:

  • Nearly 13 percent of people over the age of 12 took antidepressants in the past month from 2011 to 2014.
  • Twice as many females used antidepressants as males.
  • One-fourth of people who took antidepressants monthly had done so for at least a decade.
  • From the fifteen years between 1999 and 2014, antidepressant use in America increased by nearly 65 percent.2

Antidepressants work by correcting chemical imbalances in the brain to improve mood and influence behavior. Although these drugs cannot cure disorders like depression or social anxiety, they can reduce the negative symptoms of these issues and help individuals feel better and live more functional lives.

Are Antidepressants Addictive?

Antidepressants are not considered to be addictive because users don’t experience a euphoric high, have cravings, or demonstrate prolonged addictive behaviors when they abuse them. However, antidepressants do cause tolerance and withdrawal symptoms and people can become psychologically addicted to taking them. Although antidepressants do not produce a high, some people may still try to abuse certain ones like Wellbutrin because they do not have access to their drug of choice. This still doesn’t cause addiction, although it may produce a placebo effect. A person may also take larger doses of an antidepressant drug if he or she feels like it isn’t working fast enough or he or she may take it with alcohol to amplify its effects. Taking large doses of antidepressants can be very dangerous, may cause seizures, physical dependence, and can also result in an overdose. Although antidepressant addiction isn’t extremely common, it’s still a major risk. In instances of severe addiction, antidepressant rehab may be necessary to help someone overcome their substance use disorder.

Street Names and Slang for Antidepressants

There are certain slang terms or street names that may be used to reference antidepressants. People may use these terms to disguise their language and prevent others from knowing what they’re talking about. Street names change constantly, but the following are some of the current slang terms and street names for antidepressants:

  • Bottled Smiles
  • Happy Pill
  • Miracle Drug
  • Wonder Drug

Examples of Antidepressants

There are five main types of antidepressants.3 They include:

  1. Serotonin and noradrenaline reuptake inhibitors (SNRIs) – These drugs prevent the reabsorption of serotonin and noradrenaline so that more is available and active in the brain. SNRIs are commonly used to treat generalized anxiety, post-traumatic stress disorder, social anxiety disorder, panic disorder, and nerve pain associated with fibromyalgia.
  2. Selective serotonin reuptake inhibitors (SSRIs) – SSRIs work by preventing the reabsorption of serotonin so that more is available and active in the brain. These drugs are said to cause fewer side effects than other types of antidepressants. In addition to treating depression, they may be used to treat obsessive-compulsive disorder, generalized anxiety disorder, eating disorders, premature ejaculations, or stroke recovery.
  3. Tricyclic antidepressants (TCAs) – TCAs work by blocking the absorption of serotonin, norepinephrine, and acetylcholine. In addition to treating depression, doctors may also use TCAs to treat chronic pain.
  4. Monoamine oxidase inhibitors (MAOIs) – MAOIs prevent the action of an enzyme called monoamine oxidase to make more neurotransmitters available for mood regulation. They are not used as frequently as other types of antidepressants because they can trigger increases in blood pressure. In addition to treating depression, MAOIs can be used to treat agoraphobia, social phobia, bulimia, PTSD, borderline personality disorder, and bipolar depression.
  5. Noradrenaline and specific serotonergic antidepressants (NASSAs) – These drugs work by blocking receptors called alpha-2 receptors to enhance the action of noradrenaline and serotonin in the brain. In addition to treating depression, NASSAs can also be used to treat anxiety disorders and some personality disorders.

Some common examples of antidepressants include:

How Long Do Antidepressants Stay in Your System?

Most antidepressants will be gone from your body in four to five days although some antidepressant drugs like Prozac can take a month or more to completely leave your body.4 The amount of time a drug takes to be eliminated from your body will also depend on the dosage you were taking, its metabolism, and other personal factors like your tolerance, any medical conditions you have, and the type of antidepressant you were taking. According to Harvard Health Publishing, here’s how long the following antidepressants take to be 99 percent out of your body.5

  • Paroxetine (Paxil) – 4.4 days
  • Sertraline (Zoloft) – 5.4 days
  • Escitalopram (Lexapro) – 6.1 days
  • Citalopram (Celexa) – 7.3 days
  • Fluoxetine (Prozac) – 25 days
  • Venlafaxine (Effexor) – 1 day
  • Duloxetine (Cymbalta) – 2.5 days
  • Desvenlafaxine (Pristiq) – 2.5 days
  • Bupropion (Wellbutrin) – 4.4 days
Talk to a Treatment Expert - (512) 605-2955

What Are the Side Effects of Antidepressant Abuse?

The side effects of antidepressant abuse can vary depending on the type of antidepressant being misused, but here are some of the possible side effects:

  • Seizures
  • Insomnia
  • Irritability
  • Confusion
  • Sore throat
  • Shakiness
  • Headache
  • Paranoia
  • Hallucinations
  • Blurry vision
  • Sexual dysfunction/reduced sex drive
  • Weight gain
  • Lack of emotion6

High doses of antidepressants also increase the risk of suicide in teens and young adults ages 18 to 25.

What Are the Signs of Antidepressant Overdose?

The risk of overdose also greatly increases with antidepressant abuse. You are much more likely to overdose on antidepressant drugs if you take large doses of them or use them with alcohol or other drugs. Signs of an antidepressant overdose can range from mild to severe and may include:

  • Dilated pupils
  • Confusion
  • Headache
  • Drowsiness
  • Dry mouth
  • Fever
  • Blurry vision
  • High blood pressure
  • Nausea and vomiting
  • Hallucinations
  • Serotonin syndrome
  • Abnormally fast heart rate
  • Seizures
  • Tremors
  • Low blood pressure
  • Coma
  • Cardiac arrest
  • Respiratory depression
  • Death7

If you believe that you or a loved one is experiencing an overdose caused by antidepressants, you should call 911 immediately.

Antidepressant Withdrawal Symptoms

Unlike with addictive drugs, withdrawal symptoms from antidepressants aren’t caused by addiction, rather, they are the consequences of the chemical balance in the brain being altered when you stop taking them. Not all people will experience antidepressant withdrawal symptoms, but many do. If you have used antidepressants for months or years, it may be difficult to stop due to uncomfortable antidepressant withdrawal symptoms such as:

  • Anxiety
  • Depression
  • Mood swings
  • Dizziness and balance problems
  • Electric shock sensations
  • Fatigue
  • Flu-like symptoms
  • Headache
  • Loss of coordination
  • Muscle spasms
  • Nausea
  • Nightmares
  • Tremors
  • Trouble sleeping
  • Vomiting
  • Mania
  • Confusion
  • Psychosis8

If you are trying to stop using antidepressants, quitting cold turkey is never recommended and this method can cause severe antidepressant withdrawal symptoms. The safest and easiest way to quit antidepressants is to gradually taper your use with the help of a doctor or a medical detox program.

Antidepressant Withdrawal Timeline

The duration of antidepressant withdrawal will vary from person to person. For some, withdrawal symptoms will go away within a matter of days but others may experience withdrawal symptoms for months after first initiating antidepressant detox. Additionally, some people may have very mild symptoms and others may have severe ones.9 It is often very difficult to determine how long antidepressant withdrawal lasts because the withdrawal effects can overlap with symptoms of depression and anxiety, making it nearly impossible to distinguish between the two.

What Are the Signs of Antidepressant Addiction?

Common signs of a psychological antidepressant addiction include:

  • Continue abusing antidepressants despite the risks
  • Express a desire to stop using antidepressants but be unable to
  • Withdraw from friends and family members
  • Mix other drugs or alcohol with antidepressants
  • Take larger or more frequent doses of antidepressants
  • Steal antidepressants from loved ones, clinics, or pharmacies

How to Overcome An Antidepressant Addiction

Although antidepressants don’t cause physical addiction, it can still seem impossible to break your physical dependence and psychological addiction. If you’re struggling with an antidepressant addiction, you should know that you’re not alone. Many people struggle with the same issue and have successfully overcome it. Antidepressant detox is a great way to start a new life of sobriety. During detox, you’ll receive medical and clinical care to reduce the symptoms of antidepressant withdrawal and address any returning symptoms of depression and/or anxiety. Clinical care and monitoring during antidepressant detox can also help you prepare for entry into an inpatient or outpatient treatment program that will further address the contributing causes of your addictive behaviors. Your treatment team during antidepressant rehab can also help you learn how to cope with symptoms of depression and anxiety by exploring healthy alternatives to antidepressants. When you’re ready to get sober, a comprehensive addiction treatment plan that incorporates medical detox, antidepressant rehab, and aftercare can help you achieve a life of sobriety. Call (888) 343-1967  to speak with a representative at Nova Recovery Center about your antidepressant treatment options.

Could you have an addiction to antidepressants?
Take this confidential antidepressants use disorder assessment.


  1. https://www.medicalnewstoday.com/kc/antidepressants-work-248320
  2. https://www.cdc.gov/nchs/products/databriefs/db283.htm
  3. https://www.verywellmind.com/what-are-the-major-classes-of-antidepressants-1065086
  4. https://psycheducation.org/treatment/treatment-details/how-long-does-it-take-for-a-medication-to-go-away-when-i-stop-taking-it/
  5. https://www.health.harvard.edu/diseases-and-conditions/going-off-antidepressants
  6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140701/
  7. https://www.healthline.com/health/can-you-overdose-on-antidepressants
  8. https://www.webmd.com/depression/guide/withdrawal-from-antidepressants#1
  9. http://prescribeddrug.org/wp-content/uploads/2018/10/APPG-PDD-Survey-of-antidepressant-withdrawal-experiences.pdf

Nova Recovery Center offers a large range of substance abuse treatment services: detox, residential, outpatient and sober living.

Contact Us For Help 100% Free & Confidential

Treatment Options

Treatment Locations

We Accept Many Insurances

Call (888) 424-4029 to verify your benefits.

Call Us Now and Begin Healing at (512) 605-2955
Or text us and we will call you right back.

Not quite ready for a call? You can fill out the form below.

What Makes Us Different

  • Gender-specific treatment
  • Evidenced-based treatment
  • 12-Step immersion
  • 90-day residential treatment
  • Family program
  • Full continuum of care
  • Insurance and private pay

100% Confidential Guarantee

Confidential Consultation

Nova Recovery Center is dedicated to helping you or your loved one get help. Please call or fill out this form for a confidential consultation.

One of our understanding, dedicated advisors will contact you about your options. Begin healing today.

Nova Recovery Center is dedicated to helping you or your loved one get help. Please call or fill out this form for a confidential consultation. One of our understanding, dedicated advisors will contact you about your options. Begin healing today.

Call Now Button